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| Andrea Mozzarelli, Stefano Bettati | ||||
| Wiley | ||||
| 2011 | ||||
| English | ||||
| 476 pages | ||||
| 3.92 MB | ||||
[tab] [content title="Summary"] Scientists are actively developing oxygen therapeutics, commonly referred to as "blood substitutes," which possess the same oxygen-carrying capabilities as blood. These therapeutics can serve as alternatives to blood transfusions or as treatments for conditions where oxygen transport is compromised. This book connects the fundamental biochemical principles of the field with innovative chemical and biotechnological developments and preclinical research. It begins by emphasizing the necessity of a thorough understanding of oxygen and nitric oxide, homeostasis, and regulation, along with the established correlations between the adverse effects of specific products and their biochemical-physiological properties. ### Content Overview: - **Introduction** by Richard B. Weiskopf - **Oxygen: Chemistry, Biochemistry, Physiology, and Toxicity**: Discussing hemoglobin reactivity and regulation (Stefano Bettati, Andrea Mozzarelli) - **Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery** (Raymond C. Koehler) - **Key Players**: Hemoglobin, myoglobin, nitric oxide, and oxygen (Tim J. McMahon, Joseph Bonaventura) - **Reactive Oxygen and Nitrogen Species** in ischemia/reperfusion injury (Ester Spagnolli, Warren M. Zapol) - **Medical Needs**: Addressing acute traumatic hemorrhage and anemia (Lena M. Napolitano) - **Diagnosis and Treatment of Hemorrhages in Non-surgical Patients** (Umberto Rossi, Rosa Chianese) - **Management of Perioperative Bleeding** (Sibylle A. Kozek-Langenecker) - **Oxygenation in the Preterm Neonate** (Vidheya Venkatesh et al.) - **Ischemia** (Hooman Mirzakhani, Ala Nozari) - **Oxygen Therapy** for ischemic stroke and neurological conditions (Ari Moskowitz et al.) - **Transfusion Therapy** in thalassemia and sickle cell disease (Carlo Brugnara, Lucia De Franceschi) - **Blood Supply Strategies**: Addressing political and logistic issues (John R. Hess, Giuliano Grazzini) - **Patient Blood Management**: Issues of conscientious objection (Kenneth E. Nollet, Hitoshi Ohto) - **Clinical Practice of Red-Cell Transfusion** (Harvey G. Klein) - **Red Cell Incompatibility**: Causes and consequences (Chisa Yamada, Robertson Davenport) - **Storage Biochemistry** of red blood cells (Ryan Stapley et al.) - **Proteomic Investigations** of stored red blood cells (Lello Zolla et al.) - **Stem Cell-Derived Red Blood Cells** (Anna Rita Migliaccio et al.) - **Universal Red Blood Cell Concepts** (Luca Ronda, Serena Faggiano) - **Allosteric Effectors of Hemoglobin**: Historical and future perspectives (Martin K. Safo, Stefano Bruno) - **Hemoglobin-Based Oxygen Carriers**: History, limitations, and clinical trials (Jonathan S. Jahr et al.) - **Natural and Artificial Oxygen Carriers** (Enrico Bucci) - **Crosslinked and Polymerized Hemoglobins** as potential substitutes (Kenneth W. Olsen, Eugene Tarasov) - **Engineering Molecular Shapes of PEG-Hemoglobin Adducts** (Seetharama A. Acharya et al.) - **Hb Octamers**: Innovations with surface cysteines (Véronique Baudin-Creuza et al.) - **Hemoglobin Vesicles** as a cellular-type oxygen carrier (Hiromi Sakai et al.) - **Preclinical Safety Evaluation**: Using animal models and oxidative biomarkers (Paul W. Buehler, Felice D'Agnillo) - **Academia-Industry Collaboration** in blood substitute development (Hae Won Kim et al.) This book serves as a comprehensive resource for understanding the complex interplay of biochemistry, clinical needs, and technological advancements in the development of effective oxygen therapeutics. [/content] [content title="Content"] [/content] [content title="Author(s)"] [/content] [/tab]
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