Handbook of Nutrition and Diet in Leukemia and Blood Disease Therapy

	Author(s):	Ronald Ross Watson, Daruka Mahadevan
	Collection:
	Publisher:	Wageningen Pers
	Year:	2016
	Langue:	English
	Pages:	373 pages
	Size:	3.40 MB
	Extension:	PDF

[tab] [content title="Summary"] This handbook offers a comprehensive overview of the latest research on the influence of nutrition on blood cells and blood-related diseases. It covers a wide range of conditions, including nutritional deficiencies, leukemias, genetic mutations, and diseases associated with an increased risk of infections. Reduced red blood cell production can lead to various nutritional disorders and anemias, often requiring iron supplementation. Anemia can cause symptoms such as fatigue, sickness, and nausea, which can further impair food intake and worsen the condition. The book highlights how changes in serum levels and blood cells impact coagulation and influence immune responses, including the production of cytokines and immunoglobulins. The interactions between blood cells and various organ systems are also explored. Nutrition plays a critical role in maintaining the health and function of blood cells. Key nutrients, such as vitamins E and C, as well as iron, are vital for blood cell production and the synthesis of proteins like hemoglobin. Other nutrients, including glutamine, L-carnitine, and taurine, also play significant roles in blood cell production and related diseases. The handbook discusses various nutritional therapies, with a focus on conditions such as stem cell transplantation, iron deficiency, cardiovascular diseases, sickle cell anemia, and sepsis. Special attention is given to nutritional therapy and management in leukemia. The primary goal of this work is to review the efficacy of nutritional approaches in treating blood diseases, reducing clinical complications, and improving the quality of life for affected patients. [/content] [content title="Content"] [/content] [content title="Author(s)"] [/content] [/tab]

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Chemistry and biochemistry of oxygen therapeutics : from transfusion to artificial blood

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	Author(s):	Andrea Mozzarelli, Stefano Bettati
	Collection:
	Publisher:	Wiley
	Year:	2011
	Langue:	English
	Pages:	476 pages
	Size:	3.92 MB
	Extension:	PDF

[tab] [content title="Summary"] Scientists are actively developing oxygen therapeutics, commonly referred to as "blood substitutes," which possess the same oxygen-carrying capabilities as blood. These therapeutics can serve as alternatives to blood transfusions or as treatments for conditions where oxygen transport is compromised. This book connects the fundamental biochemical principles of the field with innovative chemical and biotechnological developments and preclinical research. It begins by emphasizing the necessity of a thorough understanding of oxygen and nitric oxide, homeostasis, and regulation, along with the established correlations between the adverse effects of specific products and their biochemical-physiological properties. ### Content Overview: - **Introduction** by Richard B. Weiskopf - **Oxygen: Chemistry, Biochemistry, Physiology, and Toxicity**: Discussing hemoglobin reactivity and regulation (Stefano Bettati, Andrea Mozzarelli) - **Major Physiological Control Mechanisms of Blood Flow and Oxygen Delivery** (Raymond C. Koehler) - **Key Players**: Hemoglobin, myoglobin, nitric oxide, and oxygen (Tim J. McMahon, Joseph Bonaventura) - **Reactive Oxygen and Nitrogen Species** in ischemia/reperfusion injury (Ester Spagnolli, Warren M. Zapol) - **Medical Needs**: Addressing acute traumatic hemorrhage and anemia (Lena M. Napolitano) - **Diagnosis and Treatment of Hemorrhages in Non-surgical Patients** (Umberto Rossi, Rosa Chianese) - **Management of Perioperative Bleeding** (Sibylle A. Kozek-Langenecker) - **Oxygenation in the Preterm Neonate** (Vidheya Venkatesh et al.) - **Ischemia** (Hooman Mirzakhani, Ala Nozari) - **Oxygen Therapy** for ischemic stroke and neurological conditions (Ari Moskowitz et al.) - **Transfusion Therapy** in thalassemia and sickle cell disease (Carlo Brugnara, Lucia De Franceschi) - **Blood Supply Strategies**: Addressing political and logistic issues (John R. Hess, Giuliano Grazzini) - **Patient Blood Management**: Issues of conscientious objection (Kenneth E. Nollet, Hitoshi Ohto) - **Clinical Practice of Red-Cell Transfusion** (Harvey G. Klein) - **Red Cell Incompatibility**: Causes and consequences (Chisa Yamada, Robertson Davenport) - **Storage Biochemistry** of red blood cells (Ryan Stapley et al.) - **Proteomic Investigations** of stored red blood cells (Lello Zolla et al.) - **Stem Cell-Derived Red Blood Cells** (Anna Rita Migliaccio et al.) - **Universal Red Blood Cell Concepts** (Luca Ronda, Serena Faggiano) - **Allosteric Effectors of Hemoglobin**: Historical and future perspectives (Martin K. Safo, Stefano Bruno) - **Hemoglobin-Based Oxygen Carriers**: History, limitations, and clinical trials (Jonathan S. Jahr et al.) - **Natural and Artificial Oxygen Carriers** (Enrico Bucci) - **Crosslinked and Polymerized Hemoglobins** as potential substitutes (Kenneth W. Olsen, Eugene Tarasov) - **Engineering Molecular Shapes of PEG-Hemoglobin Adducts** (Seetharama A. Acharya et al.) - **Hb Octamers**: Innovations with surface cysteines (Véronique Baudin-Creuza et al.) - **Hemoglobin Vesicles** as a cellular-type oxygen carrier (Hiromi Sakai et al.) - **Preclinical Safety Evaluation**: Using animal models and oxidative biomarkers (Paul W. Buehler, Felice D'Agnillo) - **Academia-Industry Collaboration** in blood substitute development (Hae Won Kim et al.) This book serves as a comprehensive resource for understanding the complex interplay of biochemistry, clinical needs, and technological advancements in the development of effective oxygen therapeutics. [/content] [content title="Content"] [/content] [content title="Author(s)"] [/content] [/tab]

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